Anti-programmed cell death protein-1/ligand-1 therapy in different cancers.

Immunologic checkpoint blockade with antibodies against the programmed cell death protein-1 (PD-1) or its ligand (PD-L1) is an effective method for reversing cancer immunosuppression and thereby promoting immune responses against several cancer types. Anti-PD-1 and anti-PD-L1 antibodies have resulted in long-term responses with minimal side effects in significant numbers of patients with melanoma, lung, kidney, bladder and triple-negative breast cancer, as well as in chemotherapy-refractory Hodgkin disease. There is already evidence from at least one randomised trial that anti-PD-1 therapy is superior to chemotherapy in the treatment of patients with metastatic melanoma, and two anti-PD-1 antibodies, pembrolizumab and nivolumab, have been approved by the US Food and Drug Administration for the treatment of patients previously treated for metastatic melanoma. It is anticipated that approvals by drug regulatory bodies will be forthcoming in several cancers in the next months

Habitable planets around the star Gl 581?

Radial velocity surveys are now able to detect terrestrial planets at habitable distance from M-type stars. Recently, two planets with minimum masses below 10 Earth masses were reported in a triple system around the M-type star Gliese 581. Using results from atmospheric models and constraints from the evolution of Venus and Mars, we assess the habitability of planets Gl 581c and Gl 581d and we discuss the uncertainties affecting the habitable zone (HZ) boundaries determination. We provide simplified formulae to estimate the HZ limits that may be used to evaluate the astrobiological potential of terrestrial exoplanets that will hopefully be discovered in the near future. Planets Gl 581c and 'd' are near, but outside, what can be considered as the conservative HZ. Planet 'c' receives 30% more energy from its star than Venus from the Sun, with an increased radiative forcing caused by the spectral energy distribution of Gl 581. Its habitability cannot however be positively ruled out by theoretical models due to uncertainties affecting cloud properties. Irradiation conditions of planet 'd' are comparable with those of early Mars. Thanks to the warming effect of CO2-ice clouds planet 'd' might be a better candidate for the first exoplanet known to be potentially habitable. A mixture of various greenhouse gases could also maintain habitable conditions on this planet.Comment: Astronomy and Astrophysics (2007) accepted for publicatio

Identification of new transitional disk candidates in Lupus with Herschel

New data from the Herschel Space Observatory are broadening our understanding of the physics and evolution of the outer regions of protoplanetary disks in star forming regions. In particular they prove to be useful to identify transitional disk candidates. The goals of this work are to complement the detections of disks and the identification of transitional disk candidates in the Lupus clouds with data from the Herschel Gould Belt Survey. We extracted photometry at 70, 100, 160, 250, 350 and 500 $\mu$m of all spectroscopically confirmed Class II members previously identified in the Lupus regions and analyzed their updated spectral energy distributions. We have detected 34 young disks in Lupus in at least one Herschel band, from an initial sample of 123 known members in the observed fields. Using the criteria defined in Ribas et al. (2013) we have identified five transitional disk candidates in the region. Three of them are new to the literature. Their PACS-70 $\mu$m fluxes are systematically higher than those of normal T Tauri stars in the same associations, as already found in T Cha and in the transitional disks in the Chamaeleon molecular cloud. Herschel efficiently complements mid-infrared surveys for identifying transitional disk candidates and confirms that these objects seem to have substantially different outer disks than the T Tauri stars in the same molecular clouds.Comment: Accepted for publication in A&A. 16 pages, 9 figures, 7 table

Small-scale Intensity Mapping: Extended Halos as a Probe of the Ionizing Escape Fraction and Faint Galaxy Populations during Reionization

We present a new method to quantify the value of the escape fraction of ionizing photons, and the existence of ultra-faint galaxies clustered around brighter objects during the epoch of cosmic reionization, using the diffuse Ly$\alpha$, continuum and H$\alpha$ emission observed around galaxies at $z\sim6$. We model the surface brightness profiles of the diffuse halos considering the fluorescent emission powered by ionizing photons escaping from the central galaxies, and the nebular emission from satellite star-forming sources, by extending the formalisms developed in Mas-Ribas & Dijkstra (2016) and Mas-Ribas et al. (2017). The comparison between our predicted profiles and Ly$\alpha$ observations at $z=5.7$ and $z=6.6$ favors a low ionizing escape fraction, $f_{\rm esc}^{\rm ion}\sim5\%$, for galaxies in the range $-19\gtrsim M_{\rm UV} \gtrsim -21.5$. However, uncertainties and possible systematics in the observations do not allow for firm conclusions. We predict H$\alpha$ and rest-frame visible continuum observations with JWST, and show that JWST will be able to detect extended (a few tens of kpc) fluorescent H$\alpha$ emission powered by ionizing photons escaping from a bright, $L\gtrsim 5L^*$, galaxy. Such observations can differentiate fluorescent emission from nebular emission by satellite sources. We discuss how observations and stacking of several objects may provide unique constraints on the escape fraction for faint galaxies and/or the abundance of ultra-faint radiation sources.Comment: 9 pages, 4 figures, re-submitted after referee report to Ap

A census of ρ\rho Oph candidate members from Gaia DR2

The Ophiuchus cloud complex is one of the best laboratories to study the earlier stages of the stellar and protoplanetary disc evolution. The wealth of accurate astrometric measurements contained in the Gaia Data Release 2 can be used to update the census of Ophiuchus member candidates. We seek to find potential new members of Ophiuchus and identify those surrounded by a circumstellar disc. We constructed a control sample composed of 188 bona fide Ophiuchus members. Using this sample as a reference we applied three different density-based machine learning clustering algorithms (DBSCAN, OPTICS, and HDBSCAN) to a sample drawn from the Gaia catalogue centred on the Ophiuchus cloud. The clustering analysis was applied in the five astrometric dimensions defined by the three-dimensional Cartesian space and the proper motions in right ascension and declination. The three clustering algorithms systematically identify a similar set of candidate members in a main cluster with astrometric properties consistent with those of the control sample. The increased flexibility of the OPTICS and HDBSCAN algorithms enable these methods to identify a secondary cluster. We constructed a common sample containing 391 member candidates including 166 new objects, which have not yet been discussed in the literature. By combining the Gaia data with 2MASS and WISE photometry, we built the spectral energy distributions from 0.5 to 22\microm for a subset of 48 objects and found a total of 41 discs, including 11 Class II and 1 Class III new discs. Density-based clustering algorithms are a promising tool to identify candidate members of star forming regions in large astrometric databases. If confirmed, the candidate members discussed in this work would represent an increment of roughly 40% of the current census of Ophiuchus.Comment: A&A, Accepted. Abridged abstrac

On the anomaly of Balmer line profiles of A-type stars. Fundamental binary systems

In previous work, Gardiner et al. (1999) found evidence for a discrepancy between the Teff obtained from Balmer lines with that from photometry and fundamental values for A-type stars. An investigation into this anomaly is presented using Balmer line profiles of stars in binary system with fundamental values of both Teff and log g. A revision of the fundamental parameters for binary systems given by Smalley & Dworetsky (1995) is also presented. The Teff obtained by fitting Halpha and Hbeta line profiles is compared to the fundamental values and those obtained from uvby photometry. We find that the discrepancy found by Gardiner et al. (1999) for stars in the range 7000 K < Teff < 9000 K is no longer evident.Comment: 10 pages, 4 figures; Accepted by A&